hfbHealth, Food & BiotechnologyHealth, Food & Biotechnology2712-7648РОСБИОТЕХ10.36107/hfb.2019.i2.s162hfb-5Research ArticleЗДОРОВЬЕHEALTHСовременные подходы к лечению красного плоского лишаяModern Approaches to the Treatment of Lichen PlanusМасюковаС. А.MasyukovaS. A.

Масюкова Светлана Андреевна

125080, Москва, Волоколамское шоссе, дом 11

Svetlana A. Masyukova

11 Volokolamskoe highway, Moscow, 125080

skin_net@mail.ruЗемляковаС. С.ZemlyakovaS. S.

Землякова Светлана Сергеевна

125080, Москва, Волоколамское шоссе, дом 11

Svetlana S. Zemlyakova

11 Volokolamskoe highway, Moscow, 125080

svetzem@gmail.comИльинИ. В.IlyinaI. V.

Ильина Инна Валентиновна

125080, Москва, Волоколамское шоссе, дом 11

Inna V. Ilyina

11 Volokolamskoe highway, Moscow, 125080

il.inna2012@yandex.ruГладькоВ. В.GladkoV. V.

Гладько Виктор Владимирович

125080, Москва, Волоколамское шоссе, дом 11

Viktor V. Gladko

11 Volokolamskoe highway, Moscow, 125080

dr.gladko@mgupp.ruФГБОУ ВО «Московский государственный университет пищевых производств»РоссияMoscow State University of Food ProductionRussian Federation201903052021121740Copyright © Масюкова С.А., Землякова С.С., Ильин И.В., Гладько В.В., 20212021Масюкова С.А., Землякова С.С., Ильин И.В., Гладько В.В.Masyukova S.A., Zemlyakova S.S., Ilyina I.V., Gladko V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.hfb-journal.ru/jour/article/view/5

Красный плоский лишай (КПЛ) - хроническое рецидивирующее воспалительное заболевание кожи. Несмотря на то, для лечения КПЛ назначается большое количество лекарственных препаратов, у части из них отсутствует четкая доказательная база, а часть лекарств может применяться не у всех пациентов из-за проблем с профилем безопасности. Цель этого исследования: проанализировать подходы к лечению больных КПЛ, чтобы помочь врачам выбрать оптимальный способ терапии таких пациентов. Обзор статей по лечению КПЛ проводился при помощи электронных баз данных Scopus, Web of Science, Medline, PubMed, elibrary.ru. Топические кортикостероиды и ингибиторы кальциневрина являются современными препаратами первой линии. В качестве других методов лечения используются системные и тоопические ретиноиды, метотерксат, циклоспорин, гидроксихлорохин, фототерапия и другие. К сожалению, отсутствуют крупные рандомизированные контролируемые исследования для подтверждения эффективности, безопасности и переносимости некоторых методов лечения КПЛ, и многие рекомендации основаны на исследованиях с небольшими размерами выборки, отсутствием стандартизированных показателей результатов, контролируемой продолжительности лечения. Следует отметить, что во всех случаях лечение больных КПЛ должно быть комплексным, индивидуальным. В то же время необходимо уделять внимание сопутствующим заболеваниям пациента, которые нередко осложняют течение кожного заболевания. Прогноз обычно благоприятный. Назначение лечения пациентам с КПЛ должно основываться на персонифицированном подходе к каждому пациенту в зависимости от степени тяжести, формы, локализации и клинической картины.

Lichen planus (LP) is a chronic relapsing inflammatory skin disease. Despite the fact that a large number of drugs are prescribed for the treatment of LP, some of them lack a clear evidence base, and some of the drugs may not be used in all patients due to problems with the safety profile. The purpose of this study is to analyze approaches to the treatment of patients with LP to help doctors choose the best way to treat such patients. A review of articles on the treatment of LP was carried out using electronic databases of Scopus, Web of Science, Medline, PubMed and elibrary.ru. Topical corticosteroids and calcineurin inhibitors are modern first-line drugs. Unfortunately, there are no large randomized controlled trials to confirm the efficacy, safety, and tolerability of other treatment methods for LP, and many recommendations are based on trials with small sample sizes; they lack of standardized outcome indicators with controlled duration of treatment. It should be noted that in all cases the treatment of patients with lichen planus should be complex and individual. At the same time, it is necessary to pay attention to comorbid diseases of the patient, which often complicate the course of skin disease. The prognosis is usually favorable. The purpose of treatment for patients with lichen planus should be based on a personalized approach to each patient, depending on the severity, form, location and clinical feature.

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The authors declare that there are no conflicts of interest present.