hfbHealth, Food & BiotechnologyHealth, Food & Biotechnology2712-7648РОСБИОТЕХhfb-319Research ArticleЗДОРОВЬЕHEALTHАНАЛИЗ КОМПОНЕНТОВ ДЛЯ СНИЖЕНИЯ СИМПТОМОВ ДЕСИНХРОНОЗА НА ПРИМЕРЕ ОТЕЧЕСТВЕННОЙ РАЗРАБОТКИhttps://orcid.org/0000-0002-6442-1360ПчелинцеваОльга Игоревна

кандидат биологических наук, руководитель медицинского отдела; 

доцент кафедры ОТЗ с оценкой технологий здравоохранения (РМАНПО)

pchelintseva87@mail.ruhttps://orcid.org/0009-0003-3997-3395ДрухВадим Михайлович

доктор медицинских наук, генеральный директор

info@mbpharma.ruСтроиловДмитрий Александрович

кафедра экспертизы допинга и наркоконтроля, химик-аналитик

info@mbpharma.ruhttps://orcid.org/0000-0003-3172-0804КалютаТатьяна Юрьевна

Директор научно-образовательного центра клинических и биомедицинских исследований (НОЦ КБМИ), кандидат медицинских наук.

tatianakaluta@yandex.ruhttps://orcid.org/0000-0003-0344-4419ФедонниковАлександр Сергеевичfedonnikov@mail.ruhttps://orcid.org/0000-0002-2719-3629МихайловАлександр Олегович

врач-терапевт участковый отделения первичной врачебной медико-санитарной помощи ГБУЗ ККБ№2

доцент кафедры инфекционных болезней ФГБОУ ВО ТГМУ 

mao1991@mail.ruАО "МираксБиоФарма", ГБОУ ВПО РМАНПОRussian FederationАО "МираксБиоФарма"Russian FederationРХТУ им.Менделеева, кафедра экспертизы допинга и наркоконтроля; АО "МираксБиоФарма"Russian FederationСаратовский государственный медицинский университет им. В. И. РазумовскогоRussian FederationФГБОУ ВО Тихоокеанский государственный медицинский университет Минздрава РоссииRussian Federation20261310202683319Copyright © Пчелинцева О.И., Друх В.М., Строилов Д.А., Калюта Т.Ю., Федонников А.С., Михайлов А.О., 20262026Пчелинцева О.И., Друх В.М., Строилов Д.А., Калюта Т.Ю., Федонников А.С., Михайлов А.О.Пчелинцева О.И., Друх В.М., Строилов Д.А., Калюта Т.Ю., Федонников А.С., Михайлов А.О.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.hfb-journal.ru/jour/article/view/319

Джетлаг (десинхроноз) представляет собой актуальную проблему в условиях глобальной мобильности населения, наиболее часто встречающуюся у путешественников. При быстром пересечении нескольких часовых поясов возникает десинхронизация внутренних циркадных ритмов с внешними сигналами времени, что выражается нарушением сна, дневной сонливостью, снижением когнитивных функций, утомляемостью и эмоциональной нестабильностью. Эти симптомы не только ухудшают качество жизни путешественников, но и снижают профессиональную работоспособность специалистов, совершающих частые трансмеридиональные перелёты.

Существующие подходы к коррекции джетлага ограничены, так как мелатонин воздействует преимущественно на циркадную составляющую, но не устраняет утомляемость и стресс, кофеин и стимуляторы временно повышают работоспособность, но могут усугублять нарушения сна. Отсутствует комплексное решение, одновременно нормализующее сон, повышающее энергетический потенциал, снижающее стресс и защищающее клетки от оксидативного повреждения.

Представленная комбинация L-теанина, родиолы розовой, лимонника китайского, магния бисглицината, рутина, витамина B6 и витамина D3 воздействует на все ключевые звенья патогенеза джетлага, а именно - нейромедиаторный дисбаланс, гиперактивацию стресс-оси, энергетическое истощение, оксидативный стресс и сосудистые нарушения. Наличие клинически подтверждённой синергии компонентов и научно доказанную эффективность каждого из них в смежных состояниях делает данную формулу обоснованным кандидатом для комплексной коррекции симптомов джетлага.

джетлагдесинхронозциркадные ритмысонадаптогеныL-теанинродиолалимонникмагнийрутинвитамин B6витамин D3утомляемостьстрессмикроциркуляцияантиоксидантымелатонинфункциональные продукты.ReferencesAdventure-Heart, D. J., Madden, N. A., & Delfabbro, P. (2018). Effects of Vitamin B6 (Pyridoxine) and a B Complex Preparation on Dreaming and Sleep. Perceptual and motor skills, 125(3), 451–462. https://doi.org/10.1177/0031512518770326Adventure-Heart, D. J., Madden, N. A., & Delfabbro, P. (2018). Effects of Vitamin B6 (Pyridoxine) and a B Complex Preparation on Dreaming and Sleep. Perceptual and motor skills, 125(3), 451–462. https://doi.org/10.1177/0031512518770326Aivo, J., Hänninen, A., Ilonen, J., & Soilu-Hänninen, M. (2015). Vitamin D3 administration to MS patients leads to increased serum levels of latency activated peptide (LAP) of TGF-beta. Journal of neuroimmunology, 280, 12–15. https://doi.org/10.1016/j.jneuroim.2015.01.005Aivo, J., Hänninen, A., Ilonen, J., & Soilu-Hänninen, M. (2015). Vitamin D3 administration to MS patients leads to increased serum levels of latency activated peptide (LAP) of TGF-beta. Journal of neuroimmunology, 280, 12–15. https://doi.org/10.1016/j.jneuroim.2015.01.005Ametov A.S., & Kosyan A.A. (2025) Circadian Rhythm Disorder as a Factor in the Development of Metabolically Unhealthy Obesity. Doctor.ru, 24(4):79-84. (In Russ.) https://doi.org/10.31550/1727-2378-2025-24-4-79-84Ametov A.S., & Kosyan A.A. (2025) Circadian Rhythm Disorder as a Factor in the Development of Metabolically Unhealthy Obesity. Doctor.ru, 24(4):79-84. (In Russ.) https://doi.org/10.31550/1727-2378-2025-24-4-79-84Bazyar, H., Moradi, L., Zaman, F., & Zare Javid, A. (2023). The effects of rutin flavonoid supplement on glycemic status, lipid profile, atherogenic index of plasma, brain-derived neurotrophic factor (BDNF), some serum inflammatory, and oxidative stress factors in patients with type 2 diabetes mellitus: A double-blind, placebo-controlled trial. Phytotherapy research : PTR, 37(1), 271–284. https://doi.org/10.1002/ptr.7611Bazyar, H., Moradi, L., Zaman, F., & Zare Javid, A. (2023). The effects of rutin flavonoid supplement on glycemic status, lipid profile, atherogenic index of plasma, brain-derived neurotrophic factor (BDNF), some serum inflammatory, and oxidative stress factors in patients with type 2 diabetes mellitus: A double-blind, placebo-controlled trial. Phytotherapy research : PTR, 37(1), 271–284. https://doi.org/10.1002/ptr.7611Bernatoniene, J., Jakstas, V., & Kopustinskiene, D. M. (2023). Phenolic Compounds of Rhodiola rosea L. as the Potential Alternative Therapy in the Treatment of Chronic Diseases. International journal of molecular sciences, 24(15), 12293. https://doi.org/10.3390/ijms241512293Bernatoniene, J., Jakstas, V., & Kopustinskiene, D. M. (2023). Phenolic Compounds of Rhodiola rosea L. as the Potential Alternative Therapy in the Treatment of Chronic Diseases. International journal of molecular sciences, 24(15), 12293. https://doi.org/10.3390/ijms241512293Besag, F. M. C., Vasey, M. J., & Sen, A. (2023). Current evidence for adjunct pyridoxine (vitamin B6) for the treatment of behavioral adverse effects associated with levetiracetam: A systematic review. Epilepsy & behavior : E&B, 140, 109065. https://doi.org/10.1016/j.yebeh.2022.109065Besag, F. M. C., Vasey, M. J., & Sen, A. (2023). Current evidence for adjunct pyridoxine (vitamin B6) for the treatment of behavioral adverse effects associated with levetiracetam: A systematic review. Epilepsy & behavior : E&B, 140, 109065. https://doi.org/10.1016/j.yebeh.2022.109065Boyle, N. B., Billington, J., Lawton, C., Quadt, F., & Dye, L. (2022). A combination of green tea, rhodiola, magnesium and B vitamins modulates brain activity and protects against the effects of induced social stress in healthy volunteers. Nutritional neuroscience, 25(9), 1845–1859. https://doi.org/10.1080/1028415X.2021.1909204Boyle, N. B., Billington, J., Lawton, C., Quadt, F., & Dye, L. (2022). A combination of green tea, rhodiola, magnesium and B vitamins modulates brain activity and protects against the effects of induced social stress in healthy volunteers. Nutritional neuroscience, 25(9), 1845–1859. https://doi.org/10.1080/1028415X.2021.1909204Boyle, S. P., Dobson, V. L., Duthie, S. J., Hinselwood, D. C., Kyle, J. A., & Collins, A. R. (2000). Bioavailability and efficiency of rutin as an antioxidant: a human supplementation study. European journal of clinical nutrition, 54(10), 774–782. https://doi.org/10.1038/sj.ejcn.1601090Boyle, S. P., Dobson, V. L., Duthie, S. J., Hinselwood, D. C., Kyle, J. A., & Collins, A. R. (2000). Bioavailability and efficiency of rutin as an antioxidant: a human supplementation study. European journal of clinical nutrition, 54(10), 774–782. https://doi.org/10.1038/sj.ejcn.1601090Cataldi, A., Gasbarro, V., Viaggi, R., Soverini, R., Gresta, E., & Mascoli, F. (2001). Efficacia clinica di un'asociazione di alfatocoferoli, rutina, meliloto e centella asiatica nel trattamento di pazienti con insufficienza venosa cronica [Effectiveness of the combination of alpha tocopherol, rutin, melilotus, and centella asiatica in the treatment of patients with chronic venous insufficiency]. Minerva cardioangiologica, 49(2), 159–163.Cataldi, A., Gasbarro, V., Viaggi, R., Soverini, R., Gresta, E., & Mascoli, F. (2001). Efficacia clinica di un'asociazione di alfatocoferoli, rutina, meliloto e centella asiatica nel trattamento di pazienti con insufficienza venosa cronica [Effectiveness of the combination of alpha tocopherol, rutin, melilotus, and centella asiatica in the treatment of patients with chronic venous insufficiency]. Minerva cardioangiologica, 49(2), 159–163.Ghavidel-Parsa, B., Naeimi, A., Gharibpoor, F., Sattari, N., Jafari, A., Masooleh, I. S., & Montazeri, A. (2022). Effect of vitamin B6 on pain, disease severity, and psychological profile of fibromyalgia patients; a randomized, double-blinded clinical trial. BMC musculoskeletal disorders, 23(1), 664. https://doi.org/10.1186/s12891-022-05637-7Ghavidel-Parsa, B., Naeimi, A., Gharibpoor, F., Sattari, N., Jafari, A., Masooleh, I. S., & Montazeri, A. (2022). Effect of vitamin B6 on pain, disease severity, and psychological profile of fibromyalgia patients; a randomized, double-blinded clinical trial. BMC musculoskeletal disorders, 23(1), 664. https://doi.org/10.1186/s12891-022-05637-7Chen, Q. G., Zeng, Y. S., Qu, Z. Q., Tang, J. Y., Qin, Y. J., Chung, P., Wong, R., & Hägg, U. (2009). The effects of Rhodiola rosea extract on 5-HT level, cell proliferation and quantity of neurons at cerebral hippocampus of depressive rats. Phytomedicine : international journal of phytotherapy and phytopharmacology, 16(9), 830–838. https://doi.org/10.1016/j.phymed.2009.03.011Chen, Q. G., Zeng, Y. S., Qu, Z. Q., Tang, J. Y., Qin, Y. J., Chung, P., Wong, R., & Hägg, U. (2009). The effects of Rhodiola rosea extract on 5-HT level, cell proliferation and quantity of neurons at cerebral hippocampus of depressive rats. Phytomedicine : international journal of phytotherapy and phytopharmacology, 16(9), 830–838. https://doi.org/10.1016/j.phymed.2009.03.011Chen, S., Kang, J., Zhu, H., Wang, K., Han, Z., Wang, L., Liu, J., Wu, Y., He, P., Tu, Y., & Li, B. (2023). L-Theanine and Immunity: A Review. Molecules (Basel, Switzerland), 28(9), 3846. https://doi.org/10.3390/molecules28093846Chen, S., Kang, J., Zhu, H., Wang, K., Han, Z., Wang, L., Liu, J., Wu, Y., He, P., Tu, Y., & Li, B. (2023). L-Theanine and Immunity: A Review. Molecules (Basel, Switzerland), 28(9), 3846. https://doi.org/10.3390/molecules28093846Corsale, I., Carrieri, P., Martellucci, J., Piccolomini, A., Verre, L., Rigutini, M., & Panicucci, S. (2018). Flavonoid mixture (diosmin, troxerutin, rutin, hesperidin, quercetin) in the treatment of I-III degree hemorroidal disease: a double-blind multicenter prospective comparative study. International journal of colorectal disease, 33(11), 1595–1600. https://doi.org/10.1007/s00384-018-3102-yCorsale, I., Carrieri, P., Martellucci, J., Piccolomini, A., Verre, L., Rigutini, M., & Panicucci, S. (2018). Flavonoid mixture (diosmin, troxerutin, rutin, hesperidin, quercetin) in the treatment of I-III degree hemorroidal disease: a double-blind multicenter prospective comparative study. International journal of colorectal disease, 33(11), 1595–1600. https://doi.org/10.1007/s00384-018-3102-yCracknell, R. O., Tavassoli, T., & Field, D. T. (2024). High-dose Vitamin-B6 reduces sensory over-responsivity. Journal of psychopharmacology (Oxford, England), 38(12), 1147–1156. https://doi.org/10.1177/02698811241271972Cracknell, R. O., Tavassoli, T., & Field, D. T. (2024). High-dose Vitamin-B6 reduces sensory over-responsivity. Journal of psychopharmacology (Oxford, England), 38(12), 1147–1156. https://doi.org/10.1177/02698811241271972Curtin, C. A., & Johnston, C. S. (2023). Vitamin B6 Supplementation Reduces Symptoms of Depression in College Women Taking Oral Contraceptives: A Randomized, Double-Blind Crossover Trial. Journal of dietary supplements, 20(4), 550–562. https://doi.org/10.1080/19390211.2022.2030843Curtin, C. A., & Johnston, C. S. (2023). Vitamin B6 Supplementation Reduces Symptoms of Depression in College Women Taking Oral Contraceptives: A Randomized, Double-Blind Crossover Trial. Journal of dietary supplements, 20(4), 550–562. https://doi.org/10.1080/19390211.2022.2030843Di, X., Yan, J., Zhao, Y., Zhang, J., Shi, Z., Chang, Y., & Zhao, B. (2010). L-theanine protects the APP (Swedish mutation) transgenic SH-SY5Y cell against glutamate-induced excitotoxicity via inhibition of the NMDA receptor pathway. Neuroscience, 168(3), 778–786. https://doi.org/10.1016/j.neuroscience.2010.04.019Di, X., Yan, J., Zhao, Y., Zhang, J., Shi, Z., Chang, Y., & Zhao, B. (2010). L-theanine protects the APP (Swedish mutation) transgenic SH-SY5Y cell against glutamate-induced excitotoxicity via inhibition of the NMDA receptor pathway. Neuroscience, 168(3), 778–786. https://doi.org/10.1016/j.neuroscience.2010.04.019Dowley, A., Long-Smith, C. M., Demehin, O., Nolan, Y., O'Connell, S., & O'Gorman, D. M. (2024). The bioaccessibility and tolerability of marine-derived sources of magnesium and calcium. Methods (San Diego, Calif.), 226, 28–34. https://doi.org/10.1016/j.ymeth.2024.04.009.Dowley, A., Long-Smith, C. M., Demehin, O., Nolan, Y., O'Connell, S., & O'Gorman, D. M. (2024). The bioaccessibility and tolerability of marine-derived sources of magnesium and calcium. Methods (San Diego, Calif.), 226, 28–34. https://doi.org/10.1016/j.ymeth.2024.04.009.Ehambarampillai, D., & Wan, M. L. Y. (2025). A comprehensive review of Schisandra chinensis lignans: pharmacokinetics, pharmacological mechanisms, and future prospects in disease prevention and treatment. Chinese medicine, 20(1), 47. https://doi.org/10.1186/s13020-025-01096-z.Ehambarampillai, D., & Wan, M. L. Y. (2025). A comprehensive review of Schisandra chinensis lignans: pharmacokinetics, pharmacological mechanisms, and future prospects in disease prevention and treatment. Chinese medicine, 20(1), 47. https://doi.org/10.1186/s13020-025-01096-z.Field, D. T., Cracknell, R. O., Eastwood, J. R., Scarfe, P., Williams, C. M., Zheng, Y., & Tavassoli, T. (2022). High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression. Human psychopharmacology, 37(6), e2852. https://doi.org/10.1002/hup.2852Field, D. T., Cracknell, R. O., Eastwood, J. R., Scarfe, P., Williams, C. M., Zheng, Y., & Tavassoli, T. (2022). High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression. Human psychopharmacology, 37(6), e2852. https://doi.org/10.1002/hup.2852Feng, Y., Peng, L., Liu, X., Zheng, Q., Qian, M., Deng, M., Peng, J., Li, Y., Lin, L., & Peng, Q. (2025). Rutin-Associated Hepatoprotection: A Review of Mechanisms and Therapeutic Prospects. Basic & clinical pharmacology & toxicology, 136(6), e70042. https://doi.org/10.1111/bcpt.70042Feng, Y., Peng, L., Liu, X., Zheng, Q., Qian, M., Deng, M., Peng, J., Li, Y., Lin, L., & Peng, Q. (2025). Rutin-Associated Hepatoprotection: A Review of Mechanisms and Therapeutic Prospects. Basic & clinical pharmacology & toxicology, 136(6), e70042. https://doi.org/10.1111/bcpt.70042Han, J. H., Ginde, A. A., Brown, S. M., Baughman, A., Collar, E. M., Ely, E. W., Gong, M. N., Hope, A. A., Hou, P. C., Hough, C. L., Iwashyna, T. J., Jackson, J. C., Khan, A., Orun, O. M., Patel, M. B., Raman, R., Rice, T. W., Ringwood, N., Semler, M. W., Shapiro, N. I., … Vitamin D to Improve Outcomes by Leveraging Early Treatment Network Investigators (2021). Effect of Early High-Dose Vitamin D3 Repletion on Cognitive Outcomes in Critically Ill Adults. Chest, 160(3), 909–918. https://doi.org/10.1016/j.chest.2021.03.046Han, J. H., Ginde, A. A., Brown, S. M., Baughman, A., Collar, E. M., Ely, E. W., Gong, M. N., Hope, A. A., Hou, P. C., Hough, C. L., Iwashyna, T. J., Jackson, J. C., Khan, A., Orun, O. M., Patel, M. B., Raman, R., Rice, T. W., Ringwood, N., Semler, M. W., Shapiro, N. I., … Vitamin D to Improve Outcomes by Leveraging Early Treatment Network Investigators (2021). Effect of Early High-Dose Vitamin D3 Repletion on Cognitive Outcomes in Critically Ill Adults. Chest, 160(3), 909–918. https://doi.org/10.1016/j.chest.2021.03.046Hancke, J.L., Burgos, R.A. & Ahumada, F. (1999) Schisandra chinensis. (Turcz.) Baill. Fitoterapia, 70, 451-471. http://dx.doi.org/10.1016/S0367-326X(99)00102-1Hancke, J.L., Burgos, R.A. & Ahumada, F. (1999) Schisandra chinensis. (Turcz.) Baill. Fitoterapia, 70, 451-471. http://dx.doi.org/10.1016/S0367-326X(99)00102-1Hashizume, Y., & Tandia, M. (2020). The reduction impact of monoglucosyl rutin on abdominal visceral fat: A randomized, placebo-controlled, double-blind, parallel-group. Journal of food science, 85(10), 3577–3589. https://doi.org/10.1111/1750-3841.15429Hashizume, Y., & Tandia, M. (2020). The reduction impact of monoglucosyl rutin on abdominal visceral fat: A randomized, placebo-controlled, double-blind, parallel-group. Journal of food science, 85(10), 3577–3589. https://doi.org/10.1111/1750-3841.15429He, J. L., Zhou, Z. W., Yin, J. J., He, C. Q., Zhou, S. F., & Yu, Y. (2014). Schisandra chinensis regulates drug metabolizing enzymes and drug transporters via activation of Nrf2-mediated signaling pathway. Drug design, development and therapy, 9, 127–146. https://doi.org/10.2147/DDDT.S68501He, J. L., Zhou, Z. W., Yin, J. J., He, C. Q., Zhou, S. F., & Yu, Y. (2014). Schisandra chinensis regulates drug metabolizing enzymes and drug transporters via activation of Nrf2-mediated signaling pathway. Drug design, development and therapy, 9, 127–146. https://doi.org/10.2147/DDDT.S68501Hidese, S., Ogawa, S., Ota, M., Ishida, I., Yasukawa, Z., Ozeki, M., & Kunugi, H. (2019). Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients, 11(10), 2362. https://doi.org/10.3390/nu11102362Hidese, S., Ogawa, S., Ota, M., Ishida, I., Yasukawa, Z., Ozeki, M., & Kunugi, H. (2019). Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients, 11(10), 2362. https://doi.org/10.3390/nu11102362Huyke, C., Engel, K., Simon-Haarhaus, B., Quirin, K. W., & Schempp, C. M. (2007). Composition and biological activity of different extracts from Schisandra sphenanthera and Schisandra chinensis. Planta medica, 73(10), 1116–1126. https://doi.org/10.1055/s-2007-981559Huyke, C., Engel, K., Simon-Haarhaus, B., Quirin, K. W., & Schempp, C. M. (2007). Composition and biological activity of different extracts from Schisandra sphenanthera and Schisandra chinensis. Planta medica, 73(10), 1116–1126. https://doi.org/10.1055/s-2007-981559Igarashi, K., Kobayashi, S., Mori, Y., Takagi, M., & Fukushima, Y. (2024). Effect of Dietary L-Theanine on Protein Expression in the Hippocampus of Senescence-Accelerated Mice (SAMP8). Journal of nutritional science and vitaminology, 70(3), 210–218. https://doi.org/10.3177/jnsv.70.210Igarashi, K., Kobayashi, S., Mori, Y., Takagi, M., & Fukushima, Y. (2024). Effect of Dietary L-Theanine on Protein Expression in the Hippocampus of Senescence-Accelerated Mice (SAMP8). Journal of nutritional science and vitaminology, 70(3), 210–218. https://doi.org/10.3177/jnsv.70.210Jadidi, A., Rezaei Ashtiani, A., Khanmohamadi Hezaveh, A., & Aghaepour, S. M. (2022). Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial. BMC complementary medicine and therapies, 23(1), 1. https://doi.org/10.1186/s12906-022-03814-8Jadidi, A., Rezaei Ashtiani, A., Khanmohamadi Hezaveh, A., & Aghaepour, S. M. (2022). Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial. BMC complementary medicine and therapies, 23(1), 1. https://doi.org/10.1186/s12906-022-03814-8Jayedi, A., & Zargar, M. S. (2019). Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies. Critical reviews in food science and nutrition, 59(16), 2697–2707. https://doi.org/10.1080/10408398.2018.1511967Jayedi, A., & Zargar, M. S. (2019). Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies. Critical reviews in food science and nutrition, 59(16), 2697–2707. https://doi.org/10.1080/10408398.2018.1511967Juneja, L.R., Chu, D.C., Okubo, T., Nagato, Y., & Yokogoshi, H. (1999) l-theanine-A unique amino acid of green tea and its relaxation effect in humans. Trends in Food Science & Technology, 10 (6–7), 199-204Juneja, L.R., Chu, D.C., Okubo, T., Nagato, Y., & Yokogoshi, H. (1999) l-theanine-A unique amino acid of green tea and its relaxation effect in humans. Trends in Food Science & Technology, 10 (6–7), 199-204Kakuda, T., Nozawa, A., Sugimoto, A., & Niino, H. (2002). Inhibition by theanine of binding of [3H]AMPA, [3H]kainate, and [3H]MDL 105,519 to glutamate receptors. Bioscience, biotechnology, and biochemistry, 66(12), 2683–2686. https://doi.org/10.1271/bbb.66.2683Kakuda, T., Nozawa, A., Sugimoto, A., & Niino, H. (2002). Inhibition by theanine of binding of [3H]AMPA, [3H]kainate, and [3H]MDL 105,519 to glutamate receptors. Bioscience, biotechnology, and biochemistry, 66(12), 2683–2686. https://doi.org/10.1271/bbb.66.2683Kakuda T. (2011). Neuroprotective effects of theanine and its preventive effects on cognitive dysfunction. Pharmacological research, 64(2), 162–168. https://doi.org/10.1016/j.phrs.2011.03.010Kakuda T. (2011). Neuroprotective effects of theanine and its preventive effects on cognitive dysfunction. Pharmacological research, 64(2), 162–168. https://doi.org/10.1016/j.phrs.2011.03.010Kimura, R., & Murata, T. (1971). Influence of alkylamides of glutamic acid and related compounds on the central nervous system. I. Central depressant effect of theanine. Chemical & pharmaceutical bulletin, 19(6), 1257–1261. https://doi.org/10.1248/cpb.19.1257Kimura, R., & Murata, T. (1971). Influence of alkylamides of glutamic acid and related compounds on the central nervous system. I. Central depressant effect of theanine. Chemical & pharmaceutical bulletin, 19(6), 1257–1261. https://doi.org/10.1248/cpb.19.1257Kobayashi, K., Nagato, Y., Aoi, N., Juneja, L. R., Kim, M., Yamamoto, T., & Sugimoto, S. (1998). Effects of L-theanine on the release of α-brain waves in human volunteers. Nippon Nogeikagaku Kaishi, 72(2), 153–157. https://doi.org/10.1271/nogeikagaku1924.72.153Kobayashi, K., Nagato, Y., Aoi, N., Juneja, L. R., Kim, M., Yamamoto, T., & Sugimoto, S. (1998). Effects of L-theanine on the release of α-brain waves in human volunteers. Nippon Nogeikagaku Kaishi, 72(2), 153–157. https://doi.org/10.1271/nogeikagaku1924.72.153Lai, J., Guo, M., Wang, D., Liu, K., Hu, D., & Li, J. (2023). Association Between Vitamin B6 and the Risk of Colorectal Cancer: A Meta-analysis of Observational Studies. Nutrition and cancer, 75(5), 1281–1294. https://doi.org/10.1080/01635581.2023.2191823Lai, J., Guo, M., Wang, D., Liu, K., Hu, D., & Li, J. (2023). Association Between Vitamin B6 and the Risk of Colorectal Cancer: A Meta-analysis of Observational Studies. Nutrition and cancer, 75(5), 1281–1294. https://doi.org/10.1080/01635581.2023.2191823Lee, Y., Jung, J. C., Jang, S., Kim, J., Ali, Z., Khan, I. A., & Oh, S. (2013). Anti-Inflammatory and Neuroprotective Effects of Constituents Isolated from Rhodiola rosea. Evidence-based complementary and alternative medicine : eCAM, 2013, 514049. https://doi.org/10.1155/2013/514049Lee, Y., Jung, J. C., Jang, S., Kim, J., Ali, Z., Khan, I. A., & Oh, S. (2013). Anti-Inflammatory and Neuroprotective Effects of Constituents Isolated from Rhodiola rosea. Evidence-based complementary and alternative medicine : eCAM, 2013, 514049. https://doi.org/10.1155/2013/514049Li, Y., Pham, V., Bui, M., Song, L., Wu, C., Walia, A., Uchio, E., Smith-Liu, F., & Zi, X. (2017). Rhodiola rosea L.: an herb with anti-stress, anti-aging, and immunostimulating properties for cancer chemoprevention. Current pharmacology reports, 3(6), 384–395. https://doi.org/10.1007/s40495-017-0106-1Li, Y., Pham, V., Bui, M., Song, L., Wu, C., Walia, A., Uchio, E., Smith-Liu, F., & Zi, X. (2017). Rhodiola rosea L.: an herb with anti-stress, anti-aging, and immunostimulating properties for cancer chemoprevention. Current pharmacology reports, 3(6), 384–395. https://doi.org/10.1007/s40495-017-0106-1Li, Z., He, X., Liu, F., Wang, J., & Feng, J. (2018). A review of polysaccharides from Schisandra chinensis and Schisandra sphenanthera: Properties, functions and applications. Carbohydrate polymers, 184, 178–190. https://doi.org/10.1016/j.carbpol.2017.12.058Li, Z., He, X., Liu, F., Wang, J., & Feng, J. (2018). A review of polysaccharides from Schisandra chinensis and Schisandra sphenanthera: Properties, functions and applications. Carbohydrate polymers, 184, 178–190. https://doi.org/10.1016/j.carbpol.2017.12.058Li, Z., Wang, Y., Fang, D., Wang, Y., Han, H., Zhang, X., & Chen, Z. (2026). Effects of rutin on renal function, oxidative stress and fibrosis in animal models of diabetic nephropathy: a systematic review and meta-analysis. Frontiers in pharmacology, 17, 1771010. https://doi.org/10.3389/fphar.2026.1771010Li, Z., Wang, Y., Fang, D., Wang, Y., Han, H., Zhang, X., & Chen, Z. (2026). Effects of rutin on renal function, oxidative stress and fibrosis in animal models of diabetic nephropathy: a systematic review and meta-analysis. Frontiers in pharmacology, 17, 1771010. https://doi.org/10.3389/fphar.2026.1771010Mattioli, L., & Perfumi, M. (2007). Rhodiola rosea L. extract reduces stress- and CRF-induced anorexia in rats. Journal of psychopharmacology (Oxford, England), 21(7), 742–750. https://doi.org/10.1177/0269881106074064Mattioli, L., & Perfumi, M. (2007). Rhodiola rosea L. extract reduces stress- and CRF-induced anorexia in rats. Journal of psychopharmacology (Oxford, England), 21(7), 742–750. https://doi.org/10.1177/0269881106074064Mathrani, A., Yip, W., Sequeira-Bisson, I. R., Barnett, D., Stevenson, O., Taylor, M. W., & Poppitt, S. D. (2023). Effect of a 12-Week Polyphenol Rutin Intervention on Markers of Pancreatic β-Cell Function and Gut Microbiota in Adults with Overweight without Diabetes. Nutrients, 15(15), 3360. https://doi.org/10.3390/nu15153360Mathrani, A., Yip, W., Sequeira-Bisson, I. R., Barnett, D., Stevenson, O., Taylor, M. W., & Poppitt, S. D. (2023). Effect of a 12-Week Polyphenol Rutin Intervention on Markers of Pancreatic β-Cell Function and Gut Microbiota in Adults with Overweight without Diabetes. Nutrients, 15(15), 3360. https://doi.org/10.3390/nu15153360Mocellin, S., Briarava, M., & Pilati, P. (2017). Vitamin B6 and Cancer Risk: A Field Synopsis and Meta-Analysis. Journal of the National Cancer Institute, 109(3), 1–9. https://doi.org/10.1093/jnci/djw230Mocellin, S., Briarava, M., & Pilati, P. (2017). Vitamin B6 and Cancer Risk: A Field Synopsis and Meta-Analysis. Journal of the National Cancer Institute, 109(3), 1–9. https://doi.org/10.1093/jnci/djw230Muhamad, R., Akrivaki, A., Papagiannopoulou, G., Zavridis, P., & Zis, P. (2023). The Role of Vitamin B6 in Peripheral Neuropathy: A Systematic Review. Nutrients, 15(13), 2823. https://doi.org/10.3390/nu15132823Muhamad, R., Akrivaki, A., Papagiannopoulou, G., Zavridis, P., & Zis, P. (2023). The Role of Vitamin B6 in Peripheral Neuropathy: A Systematic Review. Nutrients, 15(13), 2823. https://doi.org/10.3390/nu15132823Noah, L., Dye, L., Bois De Fer, B., Mazur, A., Pickering, G., & Pouteau, E. (2021). Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial. Stress and health : journal of the International Society for the Investigation of Stress, 37(5), 1000–1009. https://doi.org/10.1002/smi.3051.Noah, L., Dye, L., Bois De Fer, B., Mazur, A., Pickering, G., & Pouteau, E. (2021). Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial. Stress and health : journal of the International Society for the Investigation of Stress, 37(5), 1000–1009. https://doi.org/10.1002/smi.3051.Noah, L., Morel, V., Bertin, C., Pouteau, E., Macian, N., Dualé, C., Pereira, B., & Pickering, G. (2022). Effect of a Combination of Magnesium, B Vitamins, Rhodiola, and Green Tea (L-Theanine) on Chronically Stressed Healthy Individuals-A Randomized, Placebo-Controlled Study. Nutrients, 14(9), 1863. https://doi.org/10.3390/nu14091863Noah, L., Morel, V., Bertin, C., Pouteau, E., Macian, N., Dualé, C., Pereira, B., & Pickering, G. (2022). Effect of a Combination of Magnesium, B Vitamins, Rhodiola, and Green Tea (L-Theanine) on Chronically Stressed Healthy Individuals-A Randomized, Placebo-Controlled Study. Nutrients, 14(9), 1863. https://doi.org/10.3390/nu14091863Noah, L., Pickering, G., Mazur, A., Dubray, C., Hitier, S., Dualé, C., & Pouteau, E. (2020). Impact of magnesium supplementation, in combination with vitamin B6, on stress and magnesium status: secondary data from a randomized controlled trial. Magnesium research, 33(3), 45–57. https://doi.org/10.1684/mrh.2020.0468Noah, L., Pickering, G., Mazur, A., Dubray, C., Hitier, S., Dualé, C., & Pouteau, E. (2020). Impact of magnesium supplementation, in combination with vitamin B6, on stress and magnesium status: secondary data from a randomized controlled trial. Magnesium research, 33(3), 45–57. https://doi.org/10.1684/mrh.2020.0468Nobre, A. C., Rao, A., & Owen, G. N. (2008). L-theanine, a natural constituent in tea, and its effect on mental state. Asia Pacific journal of clinical nutrition, 17 Suppl 1, 167–168.Nobre, A. C., Rao, A., & Owen, G. N. (2008). L-theanine, a natural constituent in tea, and its effect on mental state. Asia Pacific journal of clinical nutrition, 17 Suppl 1, 167–168.Ortolani, O., Caggiano, M., Mannelli, R., Gogliettino, A., & Tufano, R. (1995). Protection from ischemia-reperfusion damage in patients with stroke: the role of rutin and GSH. Transplantation proceedings, 27(5), 2877–2878.Ortolani, O., Caggiano, M., Mannelli, R., Gogliettino, A., & Tufano, R. (1995). Protection from ischemia-reperfusion damage in patients with stroke: the role of rutin and GSH. Transplantation proceedings, 27(5), 2877–2878.Obi, Y., Mikami, S., Hamano, T., Obi, Y., Tanaka, H., Shimomura, A., Rakugi, H., Inoue, T., & Isaka, Y. (2016). Intravenous Vitamin B6 Increases Resistance to Erythropoiesis-Stimulating Agents in Hemodialysis Patients: A Randomized Controlled Trial. Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 26(6), 380–390. https://doi.org/10.1053/j.jrn.2016.06.004Obi, Y., Mikami, S., Hamano, T., Obi, Y., Tanaka, H., Shimomura, A., Rakugi, H., Inoue, T., & Isaka, Y. (2016). Intravenous Vitamin B6 Increases Resistance to Erythropoiesis-Stimulating Agents in Hemodialysis Patients: A Randomized Controlled Trial. Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 26(6), 380–390. https://doi.org/10.1053/j.jrn.2016.06.004Okereke, O. I., Reynolds, C. F., 3rd, Mischoulon, D., Chang, G., Vyas, C. M., Cook, N. R., Weinberg, A., Bubes, V., Copeland, T., Friedenberg, G., Lee, I. M., Buring, J. E., & Manson, J. E. (2020). Effect of Long-term Vitamin D3 Supplementation vs Placebo on Risk of Depression or Clinically Relevant Depressive Symptoms and on Change in Mood Scores: A Randomized Clinical Trial. JAMA, 324(5), 471–480. https://doi.org/10.1001/jama.2020.10224Okereke, O. I., Reynolds, C. F., 3rd, Mischoulon, D., Chang, G., Vyas, C. M., Cook, N. R., Weinberg, A., Bubes, V., Copeland, T., Friedenberg, G., Lee, I. M., Buring, J. E., & Manson, J. E. (2020). Effect of Long-term Vitamin D3 Supplementation vs Placebo on Risk of Depression or Clinically Relevant Depressive Symptoms and on Change in Mood Scores: A Randomized Clinical Trial. JAMA, 324(5), 471–480. https://doi.org/10.1001/jama.2020.10224Olsson, E. M., von Schéele, B., & Panossian, A. G. (2009). A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue. Planta medica, 75(2), 105–112. https://doi.org/10.1055/s-0028-108834630. Panossian, A., & Wagner, H. (2005). Stimulating effect of adaptogens: an overview with particular reference to their efficacy following single dose administration. Phytotherapy research : PTR, 19(10), 819–838. https://doi.org/10.1002/ptr.1751Olsson, E. M., von Schéele, B., & Panossian, A. G. (2009). A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue. Planta medica, 75(2), 105–112. https://doi.org/10.1055/s-0028-108834630. Panossian, A., & Wagner, H. (2005). Stimulating effect of adaptogens: an overview with particular reference to their efficacy following single dose administration. Phytotherapy research : PTR, 19(10), 819–838. https://doi.org/10.1002/ptr.1751Ortolani, O., Conti, A., De Gaudio, A. R., Masoni, M., & Novelli, G. (2000). Protective effects of N-acetylcysteine and rutin on the lipid peroxidation of the lung epithelium during the adult respiratory distress syndrome. Shock (Augusta, Ga.), 13(1), 14–18. https://doi.org/10.1097/00024382-200013010-00003Ortolani, O., Conti, A., De Gaudio, A. R., Masoni, M., & Novelli, G. (2000). Protective effects of N-acetylcysteine and rutin on the lipid peroxidation of the lung epithelium during the adult respiratory distress syndrome. Shock (Augusta, Ga.), 13(1), 14–18. https://doi.org/10.1097/00024382-200013010-00003Pajuelo, D., Meissner, J. M., Negra, T., Connolly, A., & Mullor, J. L. (2024). Comparative Clinical Study on Magnesium Absorption and Side Effects After Oral Intake of Microencapsulated Magnesium (MAGSHAPETM Microcapsules) Versus Other Magnesium Sources. Nutrients, 16(24), 4367. https://doi.org/10.3390/nu16244367.Pajuelo, D., Meissner, J. M., Negra, T., Connolly, A., & Mullor, J. L. (2024). Comparative Clinical Study on Magnesium Absorption and Side Effects After Oral Intake of Microencapsulated Magnesium (MAGSHAPETM Microcapsules) Versus Other Magnesium Sources. Nutrients, 16(24), 4367. https://doi.org/10.3390/nu16244367.Petrelli, F., Deda, R., Borgonovo, K., Dognini, G., Ghilardi, M., Parati, M. C., Petrò, D., Lonati, V., Dottorini, L., & Ghidini, A. (2024). Vitamin D3 and cancer risk in healthy subjects: An umbrella review of systematic review and meta-analysis. Clinical nutrition ESPEN, 63, 776–786. https://doi.org/10.1016/j.clnesp.2024.08.014Petrelli, F., Deda, R., Borgonovo, K., Dognini, G., Ghilardi, M., Parati, M. C., Petrò, D., Lonati, V., Dottorini, L., & Ghidini, A. (2024). Vitamin D3 and cancer risk in healthy subjects: An umbrella review of systematic review and meta-analysis. Clinical nutrition ESPEN, 63, 776–786. https://doi.org/10.1016/j.clnesp.2024.08.014Pouteau, E., Kabir-Ahmadi, M., Noah, L., Mazur, A., Dye, L., Hellhammer, J., Pickering, G., & Dubray, C. (2018). Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial. PloS one, 13(12), e0208454. https://doi.org/10.1371/journal.pone.0208454.Pouteau, E., Kabir-Ahmadi, M., Noah, L., Mazur, A., Dye, L., Hellhammer, J., Pickering, G., & Dubray, C. (2018). Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial. PloS one, 13(12), e0208454. https://doi.org/10.1371/journal.pone.0208454.Ragheb, S. R., El Wakeel, L. M., Nasr, M. S., & Sabri, N. A. (2020). Impact of Rutin and Vitamin C combination on oxidative stress and glycemic control in patients with type 2 diabetes. Clinical nutrition ESPEN, 35, 128–135. https://doi.org/10.1016/j.clnesp.2019.10.015Ragheb, S. R., El Wakeel, L. M., Nasr, M. S., & Sabri, N. A. (2020). Impact of Rutin and Vitamin C combination on oxidative stress and glycemic control in patients with type 2 diabetes. Clinical nutrition ESPEN, 35, 128–135. https://doi.org/10.1016/j.clnesp.2019.10.015Rajdl, D., Racek, J., Trefil, L., Stehlik, P., Dobra, J., & Babuska, V. (2016). Effect of Folic Acid, Betaine, Vitamin B₆, and Vitamin B12 on Homocysteine and Dimethylglycine Levels in Middle-Aged Men Drinking White Wine. Nutrients, 8(1), 34. https://doi.org/10.3390/nu8010034Rajdl, D., Racek, J., Trefil, L., Stehlik, P., Dobra, J., & Babuska, V. (2016). Effect of Folic Acid, Betaine, Vitamin B₆, and Vitamin B12 on Homocysteine and Dimethylglycine Levels in Middle-Aged Men Drinking White Wine. Nutrients, 8(1), 34. https://doi.org/10.3390/nu8010034Rao, T. P., Ozeki, M., & Juneja, L. R. (2015). In Search of a Safe Natural Sleep Aid. Journal of the American College of Nutrition, 34(5), 436–447. https://doi.org/10.1080/07315724.2014.926153Rao, T. P., Ozeki, M., & Juneja, L. R. (2015). In Search of a Safe Natural Sleep Aid. Journal of the American College of Nutrition, 34(5), 436–447. https://doi.org/10.1080/07315724.2014.926153Rizzo, R., Prato, A., Scerbo, M., Saia, F., Barone, R., & Curatolo, P. (2022). Use of Nutritional Supplements Based on L-Theanine and Vitamin B6 in Children with Tourette Syndrome, with Anxiety Disorders: A Pilot Study. Nutrients, 14(4), 852. https://doi.org/10.3390/nu14040852Rizzo, R., Prato, A., Scerbo, M., Saia, F., Barone, R., & Curatolo, P. (2022). Use of Nutritional Supplements Based on L-Theanine and Vitamin B6 in Children with Tourette Syndrome, with Anxiety Disorders: A Pilot Study. Nutrients, 14(4), 852. https://doi.org/10.3390/nu14040852Satyanarayana, P. T., Suryanarayana, R., Yesupatham, S. T., Varadapuram Ramalingareddy, S. R., & Gopalli, N. A. (2024). Does Vitamin D3 Supplementation Improve Depression Scores among Rural Adolescents? A Randomized Controlled Trial. Nutrients, 16(12), 1828. https://doi.org/10.3390/nu16121828Satyanarayana, P. T., Suryanarayana, R., Yesupatham, S. T., Varadapuram Ramalingareddy, S. R., & Gopalli, N. A. (2024). Does Vitamin D3 Supplementation Improve Depression Scores among Rural Adolescents? A Randomized Controlled Trial. Nutrients, 16(12), 1828. https://doi.org/10.3390/nu16121828Schuster, J., Cycelskij, I., Lopresti, A., & Hahn, A. (2025). Magnesium Bisglycinate Supplementation in Healthy Adults Reporting Poor Sleep: A Randomized, Placebo-Controlled Trial. Nature and science of sleep, 17, 2027–2040. https://doi.org/10.2147/NSS.S524348Schuster, J., Cycelskij, I., Lopresti, A., & Hahn, A. (2025). Magnesium Bisglycinate Supplementation in Healthy Adults Reporting Poor Sleep: A Randomized, Placebo-Controlled Trial. Nature and science of sleep, 17, 2027–2040. https://doi.org/10.2147/NSS.S524348Spasov, A. A., Wikman, G. K., Mandrikov, V. B., Mironova, I. A., & Neumoin, V. V. (2000). A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine : international journal of phytotherapy and phytopharmacology, 7(2), 85–89. https://doi.org/10.1016/S0944-7113(00)80078-1Spasov, A. A., Wikman, G. K., Mandrikov, V. B., Mironova, I. A., & Neumoin, V. V. (2000). A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine : international journal of phytotherapy and phytopharmacology, 7(2), 85–89. https://doi.org/10.1016/S0944-7113(00)80078-1Ssaratikov, A. S., Krasnov, E. A., Chnikina, L. A., Duvidson, L. M., Sotova, M. I., Marina, T. F., Nechoda, M. F., Axenova, R. A., & Tscherdinzeff, S. G. (1968). Rhodiolosid, ein neues Glykosid aus Rhodiola rosea und seine pharmakologischen Eigenschaften [Rhodiolosid, a new glycoside from Rhodiola rosea and its pharmacological properties]. Die Pharmazie, 23(7), 392–395.Ssaratikov, A. S., Krasnov, E. A., Chnikina, L. A., Duvidson, L. M., Sotova, M. I., Marina, T. F., Nechoda, M. F., Axenova, R. A., & Tscherdinzeff, S. G. (1968). Rhodiolosid, ein neues Glykosid aus Rhodiola rosea und seine pharmakologischen Eigenschaften [Rhodiolosid, a new glycoside from Rhodiola rosea and its pharmacological properties]. Die Pharmazie, 23(7), 392–395.Su, D., Luo, J., Ge, J., Liu, Y., Jin, C., Xu, P., Zhang, R., Zhu, G., Yang, M., Ai, Z., & Song, Y. (2022). Raw and Wine Processed Schisandra chinensis Regulate NREM-Sleep and Alleviate Cardiovascular Dysfunction Associated with Insomnia by Modulating HPA Axis. Planta medica, 88(14), 1311–1324. https://doi.org/10.1055/a-1721-4971Su, D., Luo, J., Ge, J., Liu, Y., Jin, C., Xu, P., Zhang, R., Zhu, G., Yang, M., Ai, Z., & Song, Y. (2022). Raw and Wine Processed Schisandra chinensis Regulate NREM-Sleep and Alleviate Cardiovascular Dysfunction Associated with Insomnia by Modulating HPA Axis. Planta medica, 88(14), 1311–1324. https://doi.org/10.1055/a-1721-4971Sugiyama, T., Sadzuka, Y., Tanaka, K., & Sonobe, T. (2001). Inhibition of glutamate transporter by theanine enhances the therapeutic efficacy of doxorubicin. Toxicology letters, 121(2), 89–96. https://doi.org/10.1016/s0378-4274(01)00317-4Sugiyama, T., Sadzuka, Y., Tanaka, K., & Sonobe, T. (2001). Inhibition of glutamate transporter by theanine enhances the therapeutic efficacy of doxorubicin. Toxicology letters, 121(2), 89–96. https://doi.org/10.1016/s0378-4274(01)00317-4Supakatisant, C., & Phupong, V. (2015). Oral magnesium for relief in pregnancy-induced leg cramps: a randomised controlled trial. Maternal & child nutrition, 11(2), 139–145. https://doi.org/10.1111/j.1740-8709.2012.00440.xSupakatisant, C., & Phupong, V. (2015). Oral magnesium for relief in pregnancy-induced leg cramps: a randomised controlled trial. Maternal & child nutrition, 11(2), 139–145. https://doi.org/10.1111/j.1740-8709.2012.00440.xSzopa, A., Ekiert, R., & Ekiert, H. (2017). Current knowledge of Schisandra chinensis (Turcz.) Baill. (Chinese magnolia vine) as a medicinal plant species: a review on the bioactive components, pharmacological properties, analytical and biotechnological studies. Phytochemistry reviews : proceedings of the Phytochemical Society of Europe, 16(2), 195–218. https://doi.org/10.1007/s11101-016-9470-4Szopa, A., Ekiert, R., & Ekiert, H. (2017). Current knowledge of Schisandra chinensis (Turcz.) Baill. (Chinese magnolia vine) as a medicinal plant species: a review on the bioactive components, pharmacological properties, analytical and biotechnological studies. Phytochemistry reviews : proceedings of the Phytochemical Society of Europe, 16(2), 195–218. https://doi.org/10.1007/s11101-016-9470-4Tian, X., Sun, L., Gou, L., Ling, X., Feng, Y., Wang, L., Yin, X., & Liu, Y. (2013). Protective effect of l-theanine on chronic restraint stress-induced cognitive impairments in mice. Brain research, 1503, 24–32. https://doi.org/10.1016/j.brainres.2013.01.048Tian, X., Sun, L., Gou, L., Ling, X., Feng, Y., Wang, L., Yin, X., & Liu, Y. (2013). Protective effect of l-theanine on chronic restraint stress-induced cognitive impairments in mice. Brain research, 1503, 24–32. https://doi.org/10.1016/j.brainres.2013.01.048Van Diermen, D., Marston, A., Bravo, J., Reist, M., Carrupt, P. A., & Hostettmann, K. (2009). Monoamine oxidase inhibition by Rhodiola rosea L. roots. Journal of ethnopharmacology, 122(2), 397–401. https://doi.org/10.1016/j.jep.2009.01.007Van Diermen, D., Marston, A., Bravo, J., Reist, M., Carrupt, P. A., & Hostettmann, K. (2009). Monoamine oxidase inhibition by Rhodiola rosea L. roots. Journal of ethnopharmacology, 122(2), 397–401. https://doi.org/10.1016/j.jep.2009.01.007Vetrugno, M., Uva, M. G., Russo, V., Iester, M., Ciancaglini, M., Brusini, P., Centofanti, M., & Rossetti, L. M. (2012). Oral administration of forskolin and rutin contributes to intraocular pressure control in primary open angle glaucoma patients under maximum tolerated medical therapy. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 28(5), 536–541. https://doi.org/10.1089/jop.2012.0021Vetrugno, M., Uva, M. G., Russo, V., Iester, M., Ciancaglini, M., Brusini, P., Centofanti, M., & Rossetti, L. M. (2012). Oral administration of forskolin and rutin contributes to intraocular pressure control in primary open angle glaucoma patients under maximum tolerated medical therapy. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 28(5), 536–541. https://doi.org/10.1089/jop.2012.0021Wang, J. W., Liang, F. Y., Ouyang, X. S., Li, P. B., Pei, Z., & Su, W. W. (2018). Evaluation of neuroactive effects of ethanol extract of Schisandra chinensis, Schisandrin, and Schisandrin B and determination of underlying mechanisms by zebrafish behavioral profiling. Chinese journal of natural medicines, 16(12), 916–925. https://doi.org/10.1016/S1875-5364(18)30133-XWang, J. W., Liang, F. Y., Ouyang, X. S., Li, P. B., Pei, Z., & Su, W. W. (2018). Evaluation of neuroactive effects of ethanol extract of Schisandra chinensis, Schisandrin, and Schisandrin B and determination of underlying mechanisms by zebrafish behavioral profiling. Chinese journal of natural medicines, 16(12), 916–925. https://doi.org/10.1016/S1875-5364(18)30133-XWang, S. Y., Li, M. M., Sun, Y., Wu, J. T., Guan, W., Jiang, Y. K., Yao, H. Y., He, X. X., Yan, J. J., Chen, Q. S., Zhang, L. L., Naseem, A., Ma, X. C., Kuang, H. X., Yang, B. Y., & Liu, Y. (2025). Volatile oils of Schisandra chinensis (Turcz.) Baill alleviates Parkinson's disease by activating the Nrf2 pathway to positively regulate autophagy and oxidative stress. Bioorganic chemistry, 157, 108277. https://doi.org/10.1016/j.bioorg.2025.108277.Wang, S. Y., Li, M. M., Sun, Y., Wu, J. T., Guan, W., Jiang, Y. K., Yao, H. Y., He, X. X., Yan, J. J., Chen, Q. S., Zhang, L. L., Naseem, A., Ma, X. C., Kuang, H. X., Yang, B. Y., & Liu, Y. (2025). Volatile oils of Schisandra chinensis (Turcz.) Baill alleviates Parkinson's disease by activating the Nrf2 pathway to positively regulate autophagy and oxidative stress. Bioorganic chemistry, 157, 108277. https://doi.org/10.1016/j.bioorg.2025.108277.Williams, J. L., Everett, J. M., D'Cunha, N. M., Sergi, D., Georgousopoulou, E. N., Keegan, R. J., McKune, A. J., Mellor, D. D., Anstice, N., & Naumovski, N. (2020). The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: a Systematic Review. Plant foods for human nutrition (Dordrecht, Netherlands), 75(1), 12–23. https://doi.org/10.1007/s11130-019-00771-5Williams, J. L., Everett, J. M., D'Cunha, N. M., Sergi, D., Georgousopoulou, E. N., Keegan, R. J., McKune, A. J., Mellor, D. D., Anstice, N., & Naumovski, N. (2020). The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: a Systematic Review. Plant foods for human nutrition (Dordrecht, Netherlands), 75(1), 12–23. https://doi.org/10.1007/s11130-019-00771-5Wu, Y., Zhang, L., Li, S., & Zhang, D. (2022). Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis. Nutrition reviews, 80(3), 351–366. https://doi.org/10.1093/nutrit/nuab014Wu, Y., Zhang, L., Li, S., & Zhang, D. (2022). Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis. Nutrition reviews, 80(3), 351–366. https://doi.org/10.1093/nutrit/nuab014Wei, D. H., & Mao, Q. Q. (2020). Vitamin B6, vitamin B12 and methionine and risk of pancreatic cancer: a meta-analysis. Nutrition journal, 19(1), 111. https://doi.org/10.1186/s12937-020-00628-7Wei, D. H., & Mao, Q. Q. (2020). Vitamin B6, vitamin B12 and methionine and risk of pancreatic cancer: a meta-analysis. Nutrition journal, 19(1), 111. https://doi.org/10.1186/s12937-020-00628-7Yamada, T., Terashima, T., Kawano, S., Furuno, R., Okubo, T., Juneja, L. R., & Yokogoshi, H. (2009). Theanine, gamma-glutamylethylamide, a unique amino acid in tea leaves, modulates neurotransmitter concentrations in the brain striatum interstitium in conscious rats. Amino acids, 36(1), 21–27. https://doi.org/10.1007/s00726-007-0020-7Yamada, T., Terashima, T., Kawano, S., Furuno, R., Okubo, T., Juneja, L. R., & Yokogoshi, H. (2009). Theanine, gamma-glutamylethylamide, a unique amino acid in tea leaves, modulates neurotransmitter concentrations in the brain striatum interstitium in conscious rats. Amino acids, 36(1), 21–27. https://doi.org/10.1007/s00726-007-0020-7Yan, T., He, B., Wan, S., Xu, M., Yang, H., Xiao, F., Bi, K., & Jia, Y. (2017). Antidepressant-like effects and cognitive enhancement of Schisandra chinensis in chronic unpredictable mild stress mice and its related mechanism. Scientific reports, 7(1), 6903. https://doi.org/10.1038/s41598-017-07407-1Yan, T., He, B., Wan, S., Xu, M., Yang, H., Xiao, F., Bi, K., & Jia, Y. (2017). Antidepressant-like effects and cognitive enhancement of Schisandra chinensis in chronic unpredictable mild stress mice and its related mechanism. Scientific reports, 7(1), 6903. https://doi.org/10.1038/s41598-017-07407-1Yin, Y., Zhao, Z., Wang, X., & Wu, Q. (2025). Effects of folic acid with vitamin B12/vitamin B6 intervention on serum homocysteine metabolism and complications in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials. Frontiers in nutrition, 12, 1701310. https://doi.org/10.3389/fnut.2025.1701310Yin, Y., Zhao, Z., Wang, X., & Wu, Q. (2025). Effects of folic acid with vitamin B12/vitamin B6 intervention on serum homocysteine metabolism and complications in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials. Frontiers in nutrition, 12, 1701310. https://doi.org/10.3389/fnut.2025.1701310Yokogoshi, H., Kato, Y., Sagesaka, Y. M., Takihara-Matsuura, T., Kakuda, T., & Takeuchi, N. (1995). Reduction effect of theanine on blood pressure and brain 5-hydroxyindoles in spontaneously hypertensive rats. Bioscience, biotechnology, and biochemistry, 59(4), 615–618. https://doi.org/10.1271/bbb.59.615Yokogoshi, H., Kato, Y., Sagesaka, Y. M., Takihara-Matsuura, T., Kakuda, T., & Takeuchi, N. (1995). Reduction effect of theanine on blood pressure and brain 5-hydroxyindoles in spontaneously hypertensive rats. Bioscience, biotechnology, and biochemistry, 59(4), 615–618. https://doi.org/10.1271/bbb.59.615Yokogoshi, H., Kobayashi, M., Mochizuki, M., & Terashima, T. (1998). Effect of theanine, r-glutamylethylamide, on brain monoamines and striatal dopamine release in conscious rats. Neurochemical research, 23(5), 667–673. https://doi.org/10.1023/a:1022490806093Yokogoshi, H., Kobayashi, M., Mochizuki, M., & Terashima, T. (1998). Effect of theanine, r-glutamylethylamide, on brain monoamines and striatal dopamine release in conscious rats. Neurochemical research, 23(5), 667–673. https://doi.org/10.1023/a:1022490806093Yu, H. L., Zhang, P. P., Zhang, C., Zhang, X., Li, Z. Z., Li, W. Q., & Fu, A. S. (2019). Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery, 33(10), 954–957. https://doi.org/10.13201/j.issn.1001-1781.2019.10.013.Yu, H. L., Zhang, P. P., Zhang, C., Zhang, X., Li, Z. Z., Li, W. Q., & Fu, A. S. (2019). Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery, 33(10), 954–957. https://doi.org/10.13201/j.issn.1001-1781.2019.10.013.Zou, Z., Zhang, F., Pan, Z., Xu, J., Li, X., Sun, X., Wang, X., Qin, F., Abulizi, A., Chen, Q., & Yan, R. (2025). Assessing the therapeutic potential of rutin in alleviating symptoms of inflammatory bowel disease: a meta-analysis. Frontiers in pharmacology, 16, 1539469. https://doi.org/10.3389/fphar.2025.1539469Zou, Z., Zhang, F., Pan, Z., Xu, J., Li, X., Sun, X., Wang, X., Qin, F., Abulizi, A., Chen, Q., & Yan, R. (2025). Assessing the therapeutic potential of rutin in alleviating symptoms of inflammatory bowel disease: a meta-analysis. Frontiers in pharmacology, 16, 1539469. https://doi.org/10.3389/fphar.2025.1539469

The authors declare that there are no conflicts of interest present.