hfbHealth, Food & BiotechnologyHealth, Food & Biotechnology2712-7648РОСБИОТЕХ10.36107/hfb.2019.il.s163hfb-30Research ArticleЗДОРОВЬЕHEALTHПроблемы предпосылок шизофрении по данным молекулярно-генетических исследованийProblems of Genetic Prerequisites of Schizophrenia - Data of Molecular Genetic ResearchesРезникА. М.ReznikA. M.

Резник Александр Михайлович

125080, город Москва, Волоколамское шоссе, дом 11

Aleksandr M. Reznik

11 Volokolamskoe highway, Moscow, 125080

a.m.reznik1969@gmail.comКостюкГ. П.KostyukG. P.

Костюк Георгий Петрович

115191, город Москва, Загородное шоссе, дом 2; 125080, город Москва, Волоколамское шоссе, дом 11

Georgy P. Kostyuk

2, Zagorodnoe shosse, Moscow, 115191; 11 Volokolamskoe highway, Moscow, 125080

kgr@yandex.ruМорозоваА. Ю.MorozovaA. Y.

Морозова Анна Юрьевна

119034, город Москва, Кропоткинский переулок, дом 23

Anna Y. Morozova

23, Kropotkinsky pereulok, Moscow, 11903

hakurate77@gmail.comЗахароваН. В.ZakharovaN. V.

Захарова Наталья Вячеславовна

115191, город Москва, Загородное шоссе, дом 2

Natalia V. Zakharova

2, Zagorodnoe shosse, Moscow, 115191

nataliza80@gmail.comФГБОУ ВО «Московский государственный университет пищевых производств»РоссияMoscow University of Food ProductionRussian FederationГБУЗ г. Москвы «Психиатрическая клиническая больница № 1 им. Н. А. Алексеева Департамента здравоохранения Москвы»; ФГБОУ ВО «Московский государственный университет пищевых производств»РоссияPsychiatric Clinical Hospital № 1 named after N. A. Alexseev of Department of Healthcare of Moscow; Moscow University of Food ProductionRussian FederationФГБУ «Национальный медицинский исследовательского центра психиатрии и наркологии им. В.П. Сербского»РоссияNational Medical Research Center of Psychiatry and Narcology named after V. P. SerbskiyRussian FederationГБУЗ г. Москвы «Психиатрическая клиническая больница № 1 им. Н. А. Алексеева Департамента здравоохранения Москвы»РоссияPsychiatric Clinical Hospital № 1 named after N. A. Alexseev of Department of Healthcare of MoscowRussian Federation201905052021112745Copyright © Резник А.М., Костюк Г.П., Морозова А.Ю., Захарова Н.В., 20212021Резник А.М., Костюк Г.П., Морозова А.Ю., Захарова Н.В.Reznik A.M., Kostyuk G.P., Morozova A.Y., Zakharova N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.hfb-journal.ru/jour/article/view/30

Статья содержит обзор молекулярно-генетических исследований шизофрении последних лет, в котором прослежены проблемы ее генетических предпосылок. В статье представлены теории постоянства шизофрении в популяции. Описаны основные виды генетических отклонений, которые ассоциируются с диагнозом шизофрении. В работе освещены возникшие в процессе исследований трудности интерпретации результатов, отмечен недостаток знания о механизмах экспрессии генов, ассоциированных с шизофренией. В статье подчеркивается необходимость совместного изучения геномных вариаций и связанных с ними нейрофизиологических механизмов. Отмечается, что поиск генно-фенотипических ассоциаций до сих пор по большей части осуществлялся без учета клинико-психопатологической вариативности шизофрении и смежных с ней эндогенных психозов. Обосновывается перспективность изучения генетических вариантов, ассоциированных с частными фенотипическими проявлениями (психопатологическими симптомами, синдромами и типами течения), так как разнообразие клинической картины эндогенных психозов, скорее всего, является отражением сложной этиологии и множества патогенетических механизмов этих расстройств.

Article contains the review of a number of molecular genetic researches of schizophrenia of the last years in which some problems of her genetic prerequisites are tracked. In article theories of constancy of schizophrenia are presented to populations. Main types of genetic deviations which are associated with the diagnosis of schizophrenia are described. In work the difficulties of interpretation of results which have arisen in the course of researches are lit, the lack of knowledge of mechanisms of an expression of the genes associated with schizophrenia, need of joint studying of genomic variations and the related neurophysiological mechanisms, search of associations with private phenotypical manifestations (psychopathological symptoms and syndromes) and their combinations is noted. It is noted that the search for gene-phenotypic associations is still carried out without taking into account the clinical and psychopathological variability of schizophrenia and related disorders. The prospects of studying the genetic variants associated with frequent phenotypic manifestations (psychopathological symptoms, syndromes and types of clinical course), as well as a variety of clinical pictures of psychoses, which, as a rule, are a reflection of the general etiology and pathogenetic consequences of these disorders, are substantiated.

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The authors declare that there are no conflicts of interest present.