hfbHealth, Food & BiotechnologyHealth, Food & Biotechnology2712-7648РОСБИОТЕХ10.36107/hfb.2023.i4.s180hfb-180Research ArticleБИОТЕХНОЛОГИИBIOTECHNOLOGYМетоды коррекции микробиома кожи и предотвращения бактериальных заболеваний с использованием косметических средств на основе пробиотиков (систематический обзор предметного поля)Methods for Correcting the Skin Microbiome and Preventing Bacterial Diseases Using Cosmetic Products Based on Probiotics (Systematic Scoping Review)https://orcid.org/0000-0001-6077-5957КаночкинаМария СергеевнаKanochkinaМaria S.

Кандидат технических наук, 

Доцент кафедры «Биотехнология и технология продуктов биоорганического синтеза» ФГБОУ ВО Российский биотехнологический университет

Научный руководитель биотехнологических проектов ООО «Микробные нутриенты иммунокорректоры»

Научно-технический эксперт и эксперт по испытаниям инновационных проектов в ДПИР г. Москвы и Фонда содействия инновациям

SPIN-код: 2584-6474, AuthorID: 1087397

kanoch@yandex.ruhttps://orcid.org/0000-0002-0015-446XВольноваЕкатерина РомановнаVolnovaEkanerina R.

Доцент кафедры «Биотехнология и технология продуктов биоорганического синтеза» ФГБОУ ВО Российский биотехнологический университет

volnovaer@mgupp.ruhttps://orcid.org/0000-0002-3444-1483БакаеваКарина ВитальевнаBakaevaKarina V.

Магистр кафедры «Биотехнология и технология продуктов биоорганического синтеза» ФГБОУ ВО Российский биотехнологический университет

bakaevakv@mgupp.ruФГБОУ ВО РОСБИОТЕХ, Научно-исследовательская организация общество с ограниченной ответственностью "Микробные нутриенты иммунокорректоры"РоссияRussian Biotechnological University (BIOTECH University)Russian FederationФГБОУ ВО РОСБИОТЕХРоссияRussian Biotechnological University (BIOTECH University)Russian Federation202331122023543852Copyright © Каночкина М.С., Вольнова Е.Р., Бакаева К.В., 20242024Каночкина М.С., Вольнова Е.Р., Бакаева К.В.Kanochkina М.S., Volnova E.R., Bakaeva K.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.hfb-journal.ru/jour/article/view/180Введение

Введение. Решение проблемы поддержания баланса, обеспечение защиты и восстановление микробиома кожи является острой необходимостью в связи с тем, что заболевания кожи и подкожной клетчатки занимают 4-е место по первичной заболеваемости среди всех болезней в Российской Федерации. Анализ российских и зарубежных публикаций, посвященных применению пробиотиков с целью профилактики и лечения различных кожных заболеваний, позволил выявить проблемное поле исследований – недостаточная степень изученности и систематизации информации, касающейся применения пробиотиков в составе лечено-профилактических косметических средств.

Цель

Цель. Авторами была поставлена цель критически оценить перспективность применения косметических средств на основе пробиотических микроорганизмов при бактериальных заболеваниях кожи.

Материалы и методы

Материалы и методы. Для написания настоящего обзора использовались рецензируемые статьи, обзоры и книги, патенты, опубликованные в период с 2010 по 2022 год, на русском и английском языке. Провели поиск по следующим ключевым словам: «пробиотики», «микробиом кожи», «стафилококки», «иммунитет», «косметическое средство», «защитный механизм кожи», «микрофлора». В исследуемую подборку источников вошли 126 публикаций, размещенных в отечественных и зарубежных базах данных, таких как Scopus, Web of Science, SciHub, PubMed, Google scholar, eLlibrary и Киберлиника. При первичном анализе публикаций (анализ аннотаций) на предмет релевантности теме было отобрано 76 источников, которые в дальнейшем детально исследовали.

Результаты

Результаты. Анализ источников позволил изучить и систематизировать информацию о природе и причинах возникновения атопического дерматита, себорейного дерматита, акне и розацеа, прийти к следующим выводам: на рынке представлены преимущественно зарубежные косметические средства с использованием метаболитов или лизатов пробиотических микроорганизмов, что не позволяет достигнуть желаемого устойчивого эффекта. В данной отрасли требуется импортозамещающие технологии получения активных компонентов косметических средств. Использование пробиотических микроорганизмов в составе местной косметической терапии является перспективным направлением, так как доказан положительный эффект пробиотических культур S.thermophilus, V.filiformis, E.faecalis, L.plantarum, B.longum, S.hominis и L.johnsonii. Показана корреляция между улучшением течения заболеваний от дозы и схем применения пробиотических препаратов. Дальнейшие направления исследований включают скрининг пробиотических микроорганизмов, наиболее подходящих для лечения и профилактики вышеописанных заболеваний, разработку основы косметического средства, позволяющего сохранять пробиотические микроорганизмы в жизнеспособном состоянии, разработка технологических решений производства и хранения инновационных косметических средств.

Introduction

Introduction. Solving the problem of maintaining balance, ensuring the protection and restoration of the skin microbiome is an urgent need due to the fact that diseases of the skin and subcutaneous tissue occupy the 4th place in primary morbidity among all diseases in the Russian Federation. An analysis of Russian and foreign publications devoted to the use of probiotics for the prevention and treatment of various skin diseases has revealed a problematic field of research – an insufficient degree of knowledge and systematization of information related to the use of probiotics in the composition of therapeutic and preventive cosmetics. 

Purpose

Purpose. The authors set a goal to critically evaluate the prospects of using cosmetics based on probiotic microorganisms in bacterial skin diseases. To write this review, we used peer-reviewed articles, reviews and books, patents published between 2010 and 2022, in Russian and English. The studied collection of sources includes 126 publications published in domestic and foreign databases such as Scopus, Web of Science, SciHub, PubMed, Google scholar, eLlibrary and Cyberlinica. During the initial analysis of publications (annotation analysis), 76 sources were selected for relevance to the topic, which were further investigated in detail. 

Results

Results. The analysis of the sources allowed us to study and systematize information about the nature and causes of atopic dermatitis, seborrheic dermatitis, acne and rosacea, to come to the following conclusions: mainly foreign cosmetics using metabolites or lysates of probiotic microorganisms are on the market, which does not allow achieving the desired sustainable effect. In this industry, import-substituting technologies for the production of active components of cosmetics are required. The use of probiotic microorganisms as part of local cosmetic therapy is a promising direction, as the positive effect of S.thermophilus, V.filiformis, E.faecalis, L.plantarum, B.longum, S.hominis and L.johnsonii has been proven. A correlation has been shown between the improvement of the course of diseases from the dose and the regimens of probiotic drugs. 

Conclusion

Conclusion. Further research areas include screening of probiotic microorganisms that are most suitable for the treatment and prevention of the above-described diseases, developing the basis of a cosmetic product that allows you to keep probiotic microorganisms in a viable state, developing technological solutions for the production and storage of innovative cosmetics.

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The authors declare that there are no conflicts of interest present.